Neuronal encoding of behaviors and instrumental learning in the dorsal striatum

The dorsal striatum is instrumental in regulating motor control and goal-directed behaviors. The classical description of the two output pathways of the dorsal striatum highlights their antagonistic control over actions. However, recent experimental evidence implicates both pathways and their coordinated activities during actions. In this review, we examine the different models proposed for striatal encoding of actions during self-paced behaviors and how they can account for evidence harvested during goal-directed behaviors. We also discuss how the activation of striatal ensembles can be reshaped and reorganized to support the formation of instrumental learning and behavioral flexibility. Future work integrating these considerations may resolve controversies regarding the control of actions by striatal networks.