Related Experiment Video
Updated: Jun 5, 2025

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
Menstrual Cycle Related Changes In Human Whole Salivary pH And Salivary Leukocyte Count
1Department of Oral pathology and Microbiology College of Dental Sciences and Hospital A.B. Road, Rau, Indore.
Introduction:
Steroid sex hormones influence every system of the body including the oral cavity. It influences the composition and flow rate of saliva. The aim was to estimate the changes in human whole salivary pH and salivary leukocyte count during the various phases of menstrual cycle.
Materials And Method:
30 female patients between 18-35 years were included in the study. They were free from any systemic illness or medication. Unstimulated saliva was collected between 10AM and 11AM during the follicular (7th day), ovulatory (12th-14th days), and luteal (21st day) phases and evaluated for changes in salivary pH and leukocyte count.
Result:
The salivary pH showed significant difference in value between ovulatory and luteal phase while the salivary leukocyte count showed significant difference in values during all the three phases.
Conclusion:
Steroid sex hormones do influence the composition of saliva and thus influence the health of periodontal tissues indirectly.
Related Concept Videos
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
The Menstrual Cycle
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
Salivary Glands and Saliva
Secretory Phase
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
Disorders of the Female Reproductive System
Menses Phase
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...

