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Updated: Jun 5, 2025

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On the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment

Pantelis Charisiadis1, Themistoklis Venianakis1, Christina D Papaemmanouil1

  • 1Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece.

Magnetic Resonance in Chemistry : MRC
|December 5, 2024
PubMed

Keywords:
1H‐13C HMBC2,2,2‐trifluoroacetic acid (TFA)labile protonsline broadeningpicric acid (2,4,6‐trinitropnenol)

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Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
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