Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

133
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
133
Vaccinations01:51

Vaccinations

44.1K
Overview
44.1K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

170
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
170
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

211
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
211
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Undernutrition and tuberculosis: time to recalibrate the global response.

The Lancet. Global health·2026
Same author

Blueprint for scalable laboratory driven quality management systems: Insights from tuberculosis diagnostic pilots in India.

The Indian journal of tuberculosis·2025
Same author

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis.

The Lancet. Child & adolescent health·2025
Same author

My tuberculosis epidemiology journey: Implications for TB program interventions, activities and strategy.

The Indian journal of tuberculosis·2024
Same author

Assessing the impact of COVID-19 management on the workload of human resources working in India's National Tuberculosis Elimination Program.

BMC health services research·2024
Same author

Facilitators and Barriers for Private Health Sector Engagement for TB Care in India: A Systematic Review and Meta-Synthesis of Qualitative Research.

Global health, science and practice·2024
Same journal

Interpreting maternal and neonatal outcomes in COVID-19-affected pregnancies.

The Indian journal of medical research·2026
Same journal

Incorporating patient- and caregiver-derived needs into national cancer research priority setting in India.

The Indian journal of medical research·2026
Same journal

Advances in glioblastoma: Is there light at the end of the tunnel?

The Indian journal of medical research·2026
Same journal

Authors' response.

The Indian journal of medical research·2026
Same journal

Formulation and sensory evaluation of nutrient-dense complementary food mixes for infants and young children aligned with national nutritional standards in India: A D-optimal mixture design approach.

The Indian journal of medical research·2026
Same journal

Prevalence of hypothyroidism among pregnant women and associated feto-maternal outcomes in India: Systematic review and meta-analysis.

The Indian journal of medical research·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2025

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.1K

TB-vaccines: Current status & challenges.

Kuldeep Singh Sachdeva1, Vineet K Chadha2

  • 1Molbio Diagnostics, Verna, Goa, India.

The Indian Journal of Medical Research
|December 5, 2024
PubMed
Summary
This summary is machine-generated.

Developing new tuberculosis (TB) vaccines is crucial for global health. Current efforts focus on improving existing vaccines and exploring novel approaches to combat TB effectively in all populations.

Keywords:
Adult vaccinationBCGchallengesnewer approachesnewer vaccinespipelinetuberculosis

More Related Videos

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

896
Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System
10:11

Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System

Published on: January 31, 2018

9.3K

Related Experiment Videos

Last Updated: Jun 5, 2025

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.1K
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

896
Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System
10:11

Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System

Published on: January 31, 2018

9.3K

Area of Science:

  • Vaccinology
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health challenge, causing widespread morbidity and mortality.
  • The current Bacillus Calmette-Guérin (BCG) vaccine has limitations in efficacy across diverse populations and age groups.
  • Achieving TB elimination necessitates the development of a more effective vaccine.

Purpose of the Study:

  • To review recent advancements in TB vaccine development.
  • To discuss novel strategies and the current pipeline for new TB vaccines.
  • To highlight ongoing challenges and future directions in TB vaccinology.

Main Methods:

  • Review of recent scientific literature and clinical trial data on TB vaccines.
  • Analysis of novel vaccine approaches, including subunit, viral vector, and DNA-based vaccines.
  • Examination of strategies for BCG vaccine re-positioning and booster development.

Main Results:

  • Significant progress has been made in developing novel TB vaccine candidates.
  • Several promising vaccine candidates are in various stages of clinical trials.
  • Challenges remain in achieving broad and durable protection against TB.

Conclusions:

  • A new TB vaccine with high efficacy across all populations is essential for TB eradication.
  • Continued research and innovation in vaccine development are critical.
  • Addressing unmet challenges will pave the way for future TB vaccine success.