Related Experiment Video
Updated: Jun 5, 2025
Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
May dental implant macro and microgeometry modifications influence peri-implant bone repair in smokers? A randomized
Fabiano Ribeiro Cirano1, Andre Luis Seferian Óbice1, Felipe Fonseca Girlanda1
1Departamento de Odontologia, Universidade Paulista (UNIP), Av. Dr. Bacelar, 1212, Vila Clementino, São Paulo, 04026-002, Brazil.
Background:
This split-mouth, double-masked, randomized clinical trial aimed at evaluating the impact of different macro geometries and nano topographical modifications on peri-implant bone repair in smokers.
Methods:
Thirty-two patients who smoked at least ten cigarettes/day, with the need of a single maxillary or mandibular implant bilaterally, received two implants randomly assigned to DA - Dual Acid-Etched implants (n = 32); HCAN - healing chambers and activated nano surface (n = 32). Implant stability quotient (ISQ) was evaluated 07, 30, 60, 90, and 120 days after implant placement. Levels of bone and angiogenic markers were quantified in the peri-implant fluid after 07, 15, 30, 90, and 120 days of implant insertion. HCAN implants have a higher ISQ than DA implants at 60 days (p < 0.05).
Results:
PLGF levels were lower for HCAN implants than for DA implants at 07-day period (p < 0.05). Besides, HCAN implants presented higher levels of OPG at 30 days and OPN, BMP-9, FGF-1, PLGF, and VEGF at 90 days, compared to DA implants (p < 0.05). The levels of EGF were higher for HCAN implants at 15, 90, and 120 days compared with DA implants (p < 0.05). HCAN implants also showed lower levels of TNF-α at 07 days in comparison to DA implants (p < 0.05) but had higher levels of DKK1 at 30 days, while DA implants presented higher levels of this marker at 90 days (p < 0.05).
Conclusion:
Macro geometry and nano topographical modifications positively modulated the bone and angiogenic factors, resulting in higher production of these markers during early peri-implant bone healing and having a positive effect on implant stabilization in smokers.
Trial Registration:
RBR-10gjvcyt; date of registration: 06/12/2023 (Retrospectively registered).
