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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Optical Trapping of Nanoparticles
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Emerging nanophotonic biosensor technologies for virus detection.

Shivananju Bannur Nanjunda1, Venkatesh N Seshadri2,3, Chitra Krishnan4

  • 1Department of Electrical Engineering, Centre of Excellence in Biochemical Sensing and Imaging (CenBioSIm), Indian Institute of Technology Madras, Chennai, India.

Nanophotonics (Berlin, Germany)
|December 5, 2024
PubMed
Summary
This summary is machine-generated.

Rapid, ultrasensitive nanophotonic biosensors offer a promising solution for early virus detection, crucial for controlling infectious diseases like COVID-19. These advanced technologies enhance diagnostic accuracy and speed for widespread population testing.

Keywords:
SARS-CoV- 2 (COVID-19)diagnostic techniqueshealthcarenano or two-dimensional materialsnanophotonicsoptical biosensorsvirus detection

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Area of Science:

  • Nanophotonics
  • Biosensing
  • Medical Diagnostics

Background:

  • Viral diseases pose a significant global health threat, necessitating rapid and accurate diagnostic tools.
  • The COVID-19 pandemic highlighted the urgent need for scalable, sensitive, and affordable virus detection methods.
  • Early diagnosis is critical for patient recovery and preventing community-wide infection spread.

Purpose of the Study:

  • To comprehensively review emerging nanophotonic biosensor technologies for virus detection.
  • To focus on SARS-CoV-2 (COVID-19) detection mechanisms and their potential.
  • To analyze quantitative factors influencing biosensor performance.

Main Methods:

  • Review of nanophotonic biosensing mechanisms including localized surface plasmon resonances, surface enhanced Raman scattering, nano-FTIR, fiber Bragg gratings, and microresonators.
  • Emphasis on the role of nanomaterials and 2D materials in enhancing photonic sensing.
  • Analysis of quantitative aspects affecting limit of detection, sensitivity, specificity, and response times.

Main Results:

  • Nanophotonic biosensors demonstrate potential for ultrasensitive and rapid virus detection.
  • Localized surface plasmon resonances and surface enhanced Raman scattering show significant promise.
  • Nanomaterials and 2D materials are key enablers for advanced photonic biosensing.

Conclusions:

  • Emerging nanophotonic biosensors offer a pathway to cost-effective, lab-on-a-chip solutions for virus detection.
  • These technologies promise ultrahigh sensitivity, rapid detection, and mass manufacturability for future pandemic preparedness.
  • Continued research into photonic biosensing is vital for global health security.