SnoRNAs: The promising targets for anti-tumor therapy

Area of Science:

• Molecular Biology
• Oncology
• Genetics

Background:

• Small nucleolar RNAs (snoRNAs) are increasingly recognized as crucial molecular markers in cancer.
• Their roles extend to tumor pathology and resistance to therapies.
• Traditional research focused on 2'-O-ribose methylation and pseudouridylation.

Purpose of the Study:

• To review novel regulatory mechanisms and functional roles of snoRNAs in tumors.
• To explore the interplay between snoRNA host genes (SNHGs) and snoRNAs in cancer.
• To discuss the clinical implications and therapeutic potential of snoRNAs.

Main Methods:

• Literature review of recent studies on snoRNA regulation and function in cancer.
• Analysis of snoRNA involvement in transcriptional, post-transcriptional, and post-translational processes.
• Examination of snoRNA host gene interactions and clinical relevance.

Main Results:

• SnoRNAs exhibit diverse regulatory mechanisms beyond classical functions.
• SnoRNAs and SNHGs act synergistically in promoting tumor progression.
• SnoRNAs function as oncogenes or tumor suppressors, influencing drug resistance.

Conclusions:

• SnoRNAs represent significant biomarkers for clinical diagnosis and prognosis in cancer.
• Targeting snoRNAs offers promising therapeutic strategies for cancer treatment.
• Further research into snoRNA pathways can unlock novel drug targets.