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Evaluation of indices for the assessment and classification of keratoconus based on optical coherence tomography and
Robert Herber1, Janine Lenk1, Lisa Ramm1
1Department of Ophthalmology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Purpose:
To compare the parameters and indices of a novel swept-source optical coherence tomography device (SS-OCT, ANTERION) with those of a rotating Scheimpflug camera (RSC)-based tomograph (Pentacam) in normal and keratoconic (KC) eyes.
Methods:
This prospective, monocentric, cross-sectional study included individuals with unoperated normal and KC eyes, selecting one eye per subject. Ectasia-specific parameters analysed with the SS-OCT were difference in mean keratometry (Kmean) in the inferior and superior meridians, maximum keratometry value (Kmax), elevation of the posterior surface at the thinnest point, screening corneal objective risk of ectasia (SCORE) and thinnest point thickness. With the RSC, parameters determined were Belin/Ambrosio total deviation value (BAD-D), index of height decentration and index of vertical asymmetry. KC classification with the SS-OCT was based on the anterior and posterior radii of curvature and thinnest point thickness according to the ABCD classification of the RSC system.
Results:
This study included 117 individuals with healthy eyes and 335 eyes with KC. The indices with the highest diagnostic discriminatory ability between the two cohorts were SCORE, difference of Kmean in the inferior and superior meridians and posterior elevation of the thinnest point (SS-OCT), as well as the index of height decentration, index of vertical asymmetry and BAD-D (RSC). The classifications using SS-OCT defined mild-stage KC as Kmax, posterior elevation of the thinnest point and thinnest point thickness as ≤50.9 D, ≤30 and ≥472 μm, respectively. Moderate stage values were 51-55.9 D, 31-69 and 471-438 μm, respectively, while respective advanced stage were ≥56 D, ≥70 and ≤437 μm.
Conclusion:
The diagnostic capabilities for both devices were found to be comparable. KC classification using SS-OCT can be independently based on the anterior surface, posterior surface and corneal thickness.
