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Updated: Jun 5, 2025

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
Published on: June 15, 2018
The role of interplay between the plant plasma membrane H+-ATPase and its lipid environment
Nikita K Lapshin1, Marina S Trofimova1
1K.A. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, 35 Botanicheskaya St., Moscow 127276, Russia.
Abstract:
The mechanisms behind the regulation of plasma membrane (PM) P-type H+-ATPase in plant cells mediated by lipid-protein interactions and lateral heterogeneity of the plasma membrane are discussed. This review will focus on 1) the structural organization and mechanisms of the catalytic cycle of the enzyme, 2) phosphorylation as the primary mechanism of pump regulation; 3) the possible role of lateral heterogeneity of the plasma membrane in this process, as well as 4) the role of lipids in the H+-ATPase biosynthesis and its delivery to the plasma membrane. In addition, 5) the potential role of membrane lipids in the H+-ATPase co-localisation with secondary active transporters is speculated.
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