Timing of Intracordal Trafermin Injection in Patients With Vocal Fold Paralysis: Recommendations for a New Treatment...

Area of Science:

• Otolaryngology
• Regenerative Medicine

Background:

• Vocal fold paralysis can significantly impact quality of life.
• Intracordal trafermin injection is a potential therapeutic option.

Purpose of the Study:

• To identify factors influencing the effectiveness of intracordal trafermin injection for vocal fold paralysis.
• To determine the optimal timing for trafermin injection to maximize therapeutic benefits.

Main Methods:

• Retrospective cohort study of 177 patients receiving intracordal trafermin injection.
• Analysis of patient demographics, vocal fold paralysis onset, and voice data (MPT, PR, MFR, VHI).
• Primary endpoint: improvement in Voice Handicap Index (VHI) post-injection.

Main Results:

• No correlation found between pre-injection voice parameters (MPT, PR, MFR) and VHI improvement.
• No correlation between injection timing (>1000 days) and VHI improvement.
• Significant negative correlation between injection timing (<90 days) and VHI improvement; a 1-week delay reduced VHI by 4.87.

Conclusions:

• Intracordal trafermin injection is effective for severe vocal fold paralysis, particularly when administered early.
• Early intervention (within 90 days) enhances trafermin efficacy.
• Potential role in preventing voice and pulmonary complications in post-aortic surgery patients.