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Encapsulated Chlorhexidine Gel Use in Adolescents Undergoing Orthodontic Treatment: A Randomised Trial
Esdras de Campos França1, Alexandre Fortes Drummond2, Karina Imaculada Rosa Teixeira3
1Restorative Dentistry Department, Dentistry Faculty, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
International Dental Journal
|December 5, 2024
Summary
Slow-delivery chlorhexidine:beta-cyclodextrin (Cx:β-Cd) gel significantly improved gingival health in orthodontic patients by reducing bleeding and inflammation. This encapsulated formulation offers a more effective antiseptic compared to free chlorhexidine (Cx).
Area of Science:
- Oral hygiene research
- Periodontal disease management
- Biomaterials in dentistry
Background:
- Orthodontic patients frequently develop plaque biofilm and gingival issues during fixed appliance therapy.
- Maintaining oral hygiene is crucial for preventing complications associated with orthodontic treatment.
Purpose of the Study:
- To compare the efficacy of a slow-release chlorhexidine:beta-cyclodextrin (Cx:β-Cd) gel against free chlorhexidine (Cx) and placebo.
- To assess the impact on clinical parameters and inflammatory markers in adolescent orthodontic patients.
Main Methods:
- Double-blind, randomized controlled trial involving 116 patients aged 12-18 years.
- Application of Cx:β-Cd gel, free Cx gel, or placebo for 15 or 30 days.
- Evaluation of bleeding on probing (BOP), plaque index, and cytokine expression in gingival crevicular fluid.
Main Results:
- The Cx:β-Cd group showed significantly reduced BOP at 15 days compared to Cx and placebo groups (P < 0.001).
- Both Cx:β-Cd and Cx groups exhibited decreased pro-inflammatory cytokines (TNF-α, IFN-γ) and increased anti-inflammatory cytokine (IL-10) at 15 days (P < 0.05).
- Encapsulated gel achieved higher salivary Cx concentrations than the free gel.
Conclusions:
- Slow-delivery Cx:β-Cd gel effectively improves gingival health in adolescents undergoing orthodontic treatment.
- Encapsulated chlorhexidine demonstrates superior antiseptic properties compared to free chlorhexidine in orthodontic patients.
