Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

504
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
504
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

223
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
223
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

183
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
183
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

521
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
521
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

437
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Postsurgical Opioid Prescribing Among Injured Workers in Washington State: 2017-2020 Trends and Policy Effects.

American journal of industrial medicine·2026
Same author

The Association of First Provider Seen With Time Loss From Work Among Workers With Back Injury: A Cohort Study.

American journal of industrial medicine·2026
Same author

Associations between psychosocial factors and long-term opioid use among injured workers receiving early opioids.

American journal of industrial medicine·2024
Same author

Google's new AI Chatbot produces fake health-related evidence-then self-corrects.

PLOS digital health·2024
Same author

Impacts of State-Level Opioid Review Programs on Injured Workers and Their Health Care Providers: A Qualitative Study in Washington and Ohio.

The Milbank quarterly·2024
Same author

Identifying factors associated with physical therapy use versus non-use among injured workers with back pain in Washington State.

American journal of industrial medicine·2024
Same journal

Health Impacts of the World Trade Center Disaster-A Call to Study Those Exposed at a Young Age.

American journal of industrial medicine·2026
Same journal

Life in the Driver's Seat: A Qualitative Analysis of Rideshare Drivers' Perspectives of Their Work and Well-Being Using Reddit Posts.

American journal of industrial medicine·2026
Same journal

Response to Healthcare Workers' Workplace Violence in Colombia.

American journal of industrial medicine·2026
Same journal

Exposure to Polycyclic Aromatic Hydrocarbons, but Not to Dust or Fluorides, in the Norwegian Aluminum Industry Is Associated With Accelerated Annual Decline in Lung Function.

American journal of industrial medicine·2026
Same journal

Beyond Water, Rest, and Shade: Advancing Farmworker Heat Protection Through Partnership.

American journal of industrial medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.3K

Association Between Pre-Injury Opioid Use and Opioid Use Patterns After a Work Injury.

Deborah Fulton-Kehoe1, John Haight1, Andrea Elmore1

  • 1Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.

American Journal of Industrial Medicine
|December 5, 2024
PubMed
Summary
This summary is machine-generated.

Opioid use before a work injury significantly increases the likelihood of long-term opioid prescribing after the injury. Healthcare providers should monitor pre-injury opioid use to manage post-injury prescriptions effectively.

Keywords:
injured workerlong‐term opioidopioidprescription drug monitoring program (PDMP)workers' compensation

More Related Videos

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
07:28

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor

Published on: July 24, 2012

19.5K
Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.1K

Related Experiment Videos

Last Updated: Jun 5, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.3K
A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
07:28

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor

Published on: July 24, 2012

19.5K
Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.1K

Area of Science:

  • Occupational Health
  • Pharmacology
  • Public Health

Background:

  • Limited research exists on long-term opioid prescribing following work-related injuries.
  • Understanding pre-injury opioid use is crucial for predicting post-injury prescribing patterns.

Purpose of the Study:

  • To assess long-term opioid prescribing patterns in workers after an injury.
  • To investigate the association between pre-injury opioid use and post-injury opioid prescribing.

Main Methods:

  • Linked workers' compensation and prescription drug monitoring program (PDMP) data were utilized.
  • Opioid prescribing was analyzed for 3 months pre-injury and 1 year post-injury.

Main Results:

  • 19% of injured workers with initial opioid prescriptions had also used opioids in the 3 months prior to injury.
  • Workers with pre-injury opioid use were significantly more likely to receive opioids 9-12 months post-injury (34% vs. 7%).
  • Chronic opioid use (≥60 days) 9-12 months post-injury was substantially higher in those with prior opioid prescriptions (20% vs. 0.4%).

Conclusions:

  • A strong association exists between pre-injury opioid use and long-term opioid prescribing after work-related injuries.
  • Healthcare providers must be aware of this relationship to inform clinical practice and patient care.