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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
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Subcutaneous and Topical Tranexamic Acid Use During Rhytidectomy.

Jason D Pou1, Maya N Matabele2, Kevin M Robertson1,3

  • 1Robertson Cosmetic Clinic, Middleton, Wisconsin, U.S.A.

The Laryngoscope
|December 6, 2024
PubMed
Summary
This summary is machine-generated.

Topical and subcutaneous tranexamic acid (TXA) reduce bruising and drain output after rhytidectomy. Subcutaneous TXA further decreases operative time, blood loss, and seroma formation without increasing complications.

Keywords:
TXAbruisingdrain outputepidermolysisrhytidectomy

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Area of Science:

  • Plastic Surgery
  • Surgical Adjuncts
  • Facial Rejuvenation

Background:

  • Tranexamic acid (TXA) is explored as a rhytidectomy adjunct.
  • Debate exists regarding optimal TXA administration route, benefits, and safety.
  • This study evaluates topical versus subcutaneous TXA in rhytidectomy.

Purpose of the Study:

  • To analyze the effects of topical and subcutaneous TXA during rhytidectomy.
  • To compare outcomes between TXA administration routes and a control group.
  • To assess safety and efficacy in facial rejuvenation surgery.

Main Methods:

  • Retrospective analysis of 175 consecutive rhytidectomy patients (Aug. 2019 - Nov. 2023).
  • Three arms: no TXA (control), intraoperative topical TXA (25 mg/mL), and subcutaneous TXA (5 mg/mL).
  • Measured outcomes: drain output, bruising, operative time, estimated blood loss (EBL), and complications.

Main Results:

  • Both topical and subcutaneous TXA significantly reduced drain output and bruising compared to control.
  • Subcutaneous TXA group showed decreased operative time, EBL, and seroma formation versus control.
  • Hematoma, epidermolysis, and infection rates were similar across all groups.

Conclusions:

  • Topical and subcutaneous TXA are safe and effective adjuncts for rhytidectomy.
  • Both methods reduce key postoperative complications like drain output and bruising.
  • Subcutaneous TXA offers additional advantages in reducing operative time, EBL, and seroma rates.