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Updated: Jun 5, 2025

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
Published on: March 15, 2018
The emerging role of Rab proteins in osteoclast organelle biogenesis and function
Shiou-Ling Lu1, Takeshi Noda1,2
1Department of Oral Cellular Biology, Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Osaka, Japan.
Abstract:
Rab GTPase proteins have been extensively studied for their roles in regulating vesicle and organelle dynamics. Among the ∼60 subtypes in mammalian cells, several Rabs have been reported to play crucial roles in osteoclast biogenesis and function. In this review, we aim to provide an update on recently described Rab GTPases, Rab11, Rab32, Rab44, and Rab38, as well as Rab7, Rab3D and Rab27A in osteoclast formation and function.
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