An overview of fucoidan electrospun nanofibers: Fabrication, modification, characterizations and applications

Nanofibers provide tunable attributes which make them promising for various applications. The electrospinning technique provides nanofibers with a large surface area and eases functionalization for various food and pharmaceutical applications. Numerous biopolymers have been employed to produce nanofibers due to their biocompatibility, biodegradability, and absorbability. Among different biopolymers, algal polysaccharides have gained much attention. Fucoidan is a sulfated polysaccharide isolated from brown macroalgae with a broad range of biological properties; therefore, it is highly investigated as a functional and therapeutic agent in foods and pharmaceuticals. Thus, different chemical modifications, such as depolymerization, oversulfation, phosphorylation, amination, acetylation, and benzoylation, or conjugation and functionalization with other polymers, have been used to make them desirable for target applications. The present study comprehensively reviews the electrospinning technique, applications, and crosslinking methods, then highlights the fucoidan attributes, fabrication of fucoidan-based electrospun nanofibers, their properties and functionality for food and biomedical applications.