Randomized controlled trial of computerized working memory training for Veterans with PTSD.

Area of Science:

• Neuroscience
• Psychiatry
• Cognitive Psychology

Background:

• Posttraumatic stress disorder (PTSD) is prevalent in Veterans, often accompanied by working memory deficits.
• Standard PTSD treatments are effective but have limitations in engagement and full benefit.
• Cognitive training, specifically working memory training (WMT), is explored as an alternative for PTSD symptom reduction.

Purpose of the Study:

• To evaluate a 16-session WMT program for Veterans with PTSD.
• To assess the feasibility, acceptability, and clinical efficacy of WMT.
• To compare two levels of interference control training within the WMT program.

Main Methods:

• A 16-session working memory training program was administered to Veterans with PTSD.
• Two interference control training conditions (high and low) were compared.
• Feasibility, acceptability, and PTSD symptom severity (including re-experiencing symptoms) were assessed.

Main Results:

• The WMT program was generally feasible and acceptable for Veterans.
• Intent-to-treat analyses showed similar effects between training groups.
• Protocol-adherent participants in the high interference group showed greater re-experiencing symptom reduction (Hedges' g = 0.57).
• Overall PTSD severity significantly decreased across both groups.

Conclusions:

• Working memory training shows potential as a viable intervention for PTSD in Veterans.
• WMT may help reduce re-experiencing symptoms, particularly with higher interference control.
• Further research is needed to validate these findings and explore wider clinical outcomes.