Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.

Cell reports. Medicine·2024

Same author

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment.

Nature·2023

Same author

LIF signaling regulates outer radial glial to interneuron fate during human cortical development.

Cell stem cell·2023

Same author

Calcium and activity-dependent signaling in the developing cerebral cortex.

Development (Cambridge, England)·2022

Same author

A matter of space and time: Emerging roles of disease-associated proteins in neural development.

Neuron·2021

Same author

BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex.

Genes & development·2021

Same journal

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis.

Cell stem cell·2026

Same journal

Human stem cell-based embryo model governance: Insights from Japan.

Cell stem cell·2026

Same journal

From reconstruction to intervention: Engineered organoids as living therapeutic depots.

Cell stem cell·2026

Same journal

Long-term lessons from MATCH01 macrophage therapy in cirrhosis.

Cell stem cell·2026

Same journal

Beyond apoptosis: LSC state dictates metabolic and anti-apoptotic vulnerabilities.

Cell stem cell·2026

Same journal

Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction.

Cell stem cell·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 5, 2025

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

Engineering regional diversity: A morphogen screen for patterned brain organoids.

Georgia Panagiotakos¹, Nan Yang²

¹Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Alper Center for Neurodevelopment and Regeneration, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

|December 6, 2024

Summary

This summary is machine-generated.

Researchers developed a new platform to screen morphogen modulators for stem cell differentiation. This method enhances understanding of brain development and cellular diversity in neural organoids.

More Related Videos

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

Related Experiment Videos

Last Updated: Jun 5, 2025

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

Area of Science:

Neuroscience
Developmental Biology
Stem Cell Biology

Background:

Morphogens are crucial signaling molecules that guide nervous system development and cellular diversity.
Current methods for controlling stem cell differentiation using morphogens are limited, hindering systematic application.

Purpose of the Study:

To develop a novel platform for high-throughput screening of morphogen modulators.
To apply this platform to neural organoids to improve understanding of brain regionalization and stem cell differentiation.

Main Methods:

Integration of parallel morphogen modulator screening with single-cell sequencing.
Utilized neural organoid models to study brain development principles.

Main Results:

The platform successfully reinforced established principles of brain regionalization.
Enabled detailed cellular annotation and characterization within neural organoids.

Conclusions:

The developed platform offers a systematic approach to harnessing morphogen signals for stem cell differentiation.
This work advances the study of neural organoids and provides a powerful tool for developmental neuroscience research.