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Updated: Jun 5, 2025

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor

Published on: January 12, 2024

Retromode imaging in vitreoretinal lymphoma.

Maria Chiara Rivolta^1,2, Maria Vittoria Cicinelli^1,2, Matteo Menean^1,2

¹School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie

|December 8, 2024

Summary

This summary is machine-generated.

Retromode imaging aids in detecting vitreoretinal lymphoma (VRL) by revealing subtle retinal changes. This adjunct tool enhances lesion characterization when combined with multimodal imaging, though vitritis can limit image quality.

Keywords:

Multimodal imaging Oncology Retromode imaging Vitreoretinal lymphoma

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Last Updated: Jun 5, 2025

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Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

Published on: February 13, 2021

Area of Science:

Ophthalmology
Oncology
Medical Imaging

Background:

Vitreoretinal lymphoma (VRL) is a rare intraocular malignancy.
Accurate and early detection of VRL is crucial for effective treatment.
Multimodal imaging is essential for diagnosing and monitoring VRL.

Purpose of the Study:

To evaluate Retromode as an adjunctive diagnostic tool for VRL.
To enhance VRL lesion detection by integrating Retromode with other imaging modalities.
To assess the utility of Retromode in characterizing VRL lesions.

Main Methods:

Retrospective pilot study of six patients with biopsy-proven VRL.
Utilized Retromode alongside pseudocolor fundus photography, fundus autofluorescence (FAF), and optical coherence tomography (OCT).
Focused on the combined diagnostic value of Retromode, FAF, and OCT for VRL detection.

Main Results:

Retromode identified detailed structural abnormalities in deep retinal layers and RPE, surpassing FAF in lesion detection.
Retromode guided OCT examination by pinpointing VRL-affected areas.
Image quality and diagnostic information from Retromode were compromised in cases of vitritis.

Conclusions:

Retromode serves as a valuable adjunct in multimodal imaging for VRL diagnosis.
Its ability to delineate subtle retinal changes supports tailored diagnostic strategies.
Retromode enhances lesion detection and characterization in VRL management.