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Related Experiment Video

Updated: Jun 4, 2026

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
07:22

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Published on: March 11, 2016

Spectrally Resolved (Colour-Coded) Fundus Autofluorescence Using the EIDON System in Vitreoretinal Lymphoma.

Alessandro Marchese1,2, Riccardo Sacconi1,2, Matteo Menean1,2

  • 1School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Ophthalmology and Therapy
|June 3, 2026
PubMed
Summary
This summary is machine-generated.

Colour-coded fundus autofluorescence (FAF) aids in diagnosing vitreoretinal lymphoma (VRL) by better identifying retinitis-like lesions and lymphomatous RPE detachments compared to other FAF types.

Keywords:
Colour-coded autofluorescenceFundus autofluorescenceOptical coherence tomographyRetinal pigment epitheliumVitreoretinal lymphoma

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Published on: May 26, 2023

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Oncology

Background:

  • Vitreoretinal lymphoma (VRL) presents diagnostic challenges due to varied ocular manifestations.
  • Accurate diagnosis of VRL is crucial for timely treatment and improved patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of colour-coded fundus autofluorescence (FAF) in diagnosing VRL.
  • To compare colour-coded FAF with conventional blue and green FAF for detecting VRL lesions.

Main Methods:

  • Retrospective analysis of 20 eyes from 10 VRL patients using colour-coded FAF.
  • Comparative analysis with blue and green FAF, and optical coherence tomography.
  • Assessment of lesion detection and appearance in macular and extramacular locations.

Main Results:

  • Excellent inter-reader agreement for VRL lesion detection with colour-coded FAF.
  • Colour-coded FAF superiorly identified retinitis-like lesions and lymphomatous RPE detachments versus blue/green FAF.
  • Colour-coded FAF detected minor fluorophores, RPE atrophic areas, sub-RPE deposits, and perivascular infiltrates.

Conclusions:

  • Colour-coded FAF effectively recognizes classic VRL features.
  • This imaging modality aids in identifying subtle VRL manifestations like retinitis-like lesions and RPE detachments.
  • Colour-coded FAF serves as a valuable complementary tool for VRL diagnosis.