Development of a novel second-generation polyester dendritic functionalized graphene oxide for efficient pipette tip
Xuesong Liu1, Liuliu Cheng2, Yehong Han2
1Hebei Key Laboratory of Public Health Safety, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Science, Hebei University, Baoding 071002, China; Hebei Key Laboratory of Analytical Science and Technology, State Key Laboratory of New Pharmaceutical Preparations and Excipients, College of Chemistry and Materials Science, Hebei University, Baoding, 071002, China.
Abstract:
A novel adsorbent, second-generation polyester dendritic functionalized graphene oxide (PDG-2), was developed for pipette tip micro solid-phase extraction of venlafaxine and desvenlafaxine from urine. Leveraging the facile modification properties of graphene oxide and the controlled synthesis capabilities of dendritic materials, PDG-2 exhibited a rough surface and numerous active groups with adsorption capacities of desvenlafaxine and venlafaxine up to 187 mg g-1 and 230 mg g-1. Method validation confirmed excellent linearity, low detection limits, high precision, and accurate recovery. Compared with commercial adsorbents, PDG-2 outperformed HLB and MCX and matched the performance of C18 with a much smaller amount.
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