Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

391
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
391
Glaucoma: Overview01:25

Glaucoma: Overview

507
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
507

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetic resonance fingerprinting of the bladder is feasible in men with lower urinary tract symptoms.

Abdominal radiology (New York)·2026
Same author

Risk Factors for Falls in Older Depressed Adults Treated with Bupropion: An Analysis of the OPTIMUM Randomized Clinical Trial.

Journal of general internal medicine·2026
Same author

HPV Integration in Head and Neck Cancer: Downstream Splicing Events and Expression Ratios Linked with Poor Outcomes.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Temporal Bone Anatomy at 0.55 T: Comparison to 1.5/3T MR and High-Resolution CT.

Academic radiology·2025
Same author

Impact of neighbor-level disadvantage on survival outcomes in head and neck squamous cell carcinoma.

Cancer causes & control : CCC·2025
Same author

MRI at 0.55 T for Assessment of Pancreatic Intraductal Papillary Mucinous Neoplasms: An Intraindividual Comparison Versus 1.5-T and 3-T MRI.

AJR. American journal of roentgenology·2025

Related Experiment Video

Updated: Jun 5, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.3K

Visual Field Progression in the Ocular Hypertension Treatment Study.

Mae O Gordon1, Dale K Heuer2, Eve J Higginbotham3

  • 1From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in St Louis (M.O.G., M.A.K.), St Louis, Missouri, USA.

American Journal of Ophthalmology
|December 8, 2024
PubMed
Summary

Primary open-angle glaucoma (POAG) can cause rapid visual field loss, even in clinical trials. Ocular hypertensive patients need vigilant follow-up for early POAG diagnosis and treatment.

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K
Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

1.4K

Related Experiment Videos

Last Updated: Jun 5, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.3K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K
Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

1.4K

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Visual Field Analysis

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • The Ocular Hypertension Treatment Study (OHTS) has provided critical data on POAG progression.
  • Understanding visual field (VF) loss rates is crucial for managing POAG.

Purpose of the Study:

  • To quantify the rate of VF loss before and after POAG diagnosis in OHTS participants.
  • To compare VF loss rates in different POAG subtypes (optic disc vs. VF defect).

Main Methods:

  • Prospective analysis of data from the OHTS clinical trial.
  • Calculation of mean deviation (MD) slopes using linear regression for pre- and post-POAG diagnosis periods.
  • Inclusion of participants with a minimum of 5 VFs for each period.

Main Results:

  • The mean age at POAG diagnosis was 66.4 years; 56% were male.
  • Post-POAG VF loss rates varied: -0.40 dB/year for all POAG eyes, -0.19 dB/year for optic disc POAG only, and -0.54 dB/year for VF POAG.
  • A significant proportion of VF POAG eyes showed rapid progression (≥ -0.5 dB/year in 41%, ≥ -1.0 dB/year in 21%).

Conclusions:

  • Some POAG patients experience rapid VF loss despite clinical monitoring.
  • Ocular hypertensive individuals, particularly those at high risk for POAG, require diligent follow-up.
  • Early diagnosis and timely treatment are essential to mitigate vision loss in POAG.