Emerging therapeutic frontiers in prostate health: Novel molecular targets and classical pathways in comparison with...

Area of Science:

• Urology
• Oncology
• Molecular Biology

Background:

• Current treatments for benign prostatic hyperplasia (BPH) and prostate cancer primarily target androgen receptors (AR) and 5-alpha reductase.
• These traditional therapies often lead to significant side effects and the development of treatment resistance.
• There is a need for alternative therapeutic strategies with improved safety and efficacy profiles.

Purpose of the Study:

• To explore novel therapeutic targets and pathways for BPH and prostate cancer beyond the conventional androgen-axis.
• To compare the potential of emerging strategies against established treatments for prostate diseases.
• To highlight innovative approaches for enhancing treatment efficacy and reducing resistance.

Main Methods:

• Literature review and data compilation from scientific databases (Google Scholar, PubMed) and general search engines (Google).
• Identification and analysis of recent research on novel therapeutic targets including integrin and cadherin inhibitors, gene regulation, microRNAs, cellular senescence, and metabolomics.
• Comparative assessment of emerging targets versus traditional androgen-focused therapies.

Main Results:

• Emerging targets such as integrin/cadherin inhibitors, gene regulation, microRNAs, cellular senescence, and metabolomics pathways show promise.
• These novel approaches offer potential for more personalized treatments with fewer adverse effects.
• Modulating suppressed or overexpressed novel target sites and pathways can control signaling in prostate diseases.

Conclusions:

• Novel therapeutic targets and pathways represent a significant advancement over traditional androgen-focused treatments for BPH and prostate cancer.
• These innovative strategies hold potential for overcoming treatment resistance and minimizing side effects.
• Future treatments for prostate diseases may involve personalized approaches utilizing these emerging targets and innovative exogenous substances.