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Updated: Jun 5, 2025

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
Published on: March 1, 2024
Enhancing stability, bioavailability and nutritional intervention effect of procyanidins using bio-based delivery
Shanshan Tie1, Mengmeng Xue2, Yannan Chen3
1College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian 116034, Liaoning, China.
Abstract:
Procyanidins (PCs), a kind of polyphenolic compound, have attracted extensive attention due to their strong antioxidant, anti-inflammatory and other activities. However, PCs are susceptible to complex micro-environments, resulting in low stability, poor target tissue delivery and bioavailability, which limits their biological effects. Therefore, it is urgent to find some suitable pathways to protect PCs, avoid their degradation, and maximize their health benefits in nutritional intervention. This review focused on the design and construction of different types of bio-based delivery systems loaded with PCs, such as nanoparticles, microparticles, emulsions, liposomes, hydrogels and fibers. The advantages and biological effects of PCs-based delivery systems in promoting cellular uptake, realizing targeted release of organs, cells and organelles, and even nutritional intervention for different chronic diseases were summarized. Furthermore, the development prospects and challenges of delivery systems in the field of precision nutrition were discussed. The construction of these delivery systems can effectively improve the stability and bioavailability of PCs, and maximize their precise nutritional intervention for various chronic diseases.
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