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Uncertainty in Measurement: Accuracy and Precision

Uncertainty in Measurement: Accuracy and Precision

Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.

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Updated: Jun 5, 2025

Using Capillary Electrophoresis to Quantify Organic Acids from Plant Tissue: A Test Case Examining Coffea arabica Seeds

Using Capillary Electrophoresis to Quantify Organic Acids from Plant Tissue: A Test Case Examining Coffea arabica Seeds

Published on: November 12, 2016

[Variation in CEA Values because of Differences in CEA Measurement Methods].

Hitoshi Kameyama¹, Toshiyuki Yamazaki, Akira Iwaya

¹Dept. of Digestive Surgery, Niigata City General Hospital.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|December 8, 2024

Summary

New carcinoembryonic antigen (CEA) measurement methods show significantly higher values compared to older methods. This difference is crucial for accurate colorectal cancer monitoring and treatment decisions.

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Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements

Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements

Published on: September 7, 2019

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Last Updated: Jun 5, 2025

Using Capillary Electrophoresis to Quantify Organic Acids from Plant Tissue: A Test Case Examining Coffea arabica Seeds

Using Capillary Electrophoresis to Quantify Organic Acids from Plant Tissue: A Test Case Examining Coffea arabica Seeds

Published on: November 12, 2016

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Published on: October 27, 2020

Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements

Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements

Published on: September 7, 2019

Area of Science:

Oncology
Clinical Chemistry
Biomarker Analysis

Context:

Carcinoembryonic antigen (CEA) is a vital biomarker in colorectal cancer (CRC) management.
Assay methods for CEA have evolved, necessitating an evaluation of their impact on reported values.
Inter-method variability can affect clinical interpretation and patient care.

Purpose:

To evaluate the changes in carcinoembryonic antigen (CEA) values resulting from a switch in measurement methods.
To quantify the difference between CEA levels obtained using an old assay method and a new assay method.

Summary:

A study involving 163 colorectal cancer patients compared old and new CEA assay methods.
The new assay method (Alinity i system, CEA-Abbott) demonstrated significantly higher CEA values compared to the old method (Centaur XP/XPT, ADVIA Centaur CEA).
The mean CEA increased from 2.06 ng/mL to 3.14 ng/mL (p<0.0001), with 99.3% of new values exceeding old values.

Impact:

Findings highlight the critical need to acknowledge assay-specific differences in CEA levels.
This information is essential for consistent interpretation of CEA trends in colorectal cancer patients.
Clinicians should be aware of potential shifts in CEA values due to assay method changes to ensure appropriate patient management.