Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardizing Upper Abdominal Fascial Terminology: A Transdisciplinary Expert Consensus From the Japanese Society for Endoscopic Surgery.

Asian journal of endoscopic surgery·2026
Same author

Pathological sources of hemoptysis in severe cavitary lung disease: A serial-section study of surgical and autopsy cases.

Respiratory medicine·2026
Same author

Inter-institutional heterogeneity in high-volume esophageal cancer centers: an ancillary study of JCOG1109 (JCOG2308A).

Esophagus : official journal of the Japan Esophageal Society·2026
Same author

Usefulness of indigo carmine chromoendoscopy for detecting gastric cancer and gastric adenoma during upper gastrointestinal endoscopy (INDIGO study): protocol for a prospective multicentre observational study.

BMJ open gastroenterology·2026
Same author

Job resignation between cancer diagnosis and surgery in patients with gastric and esophageal cancer: a multi-institutional cross-sectional study.

International journal of clinical oncology·2026
Same author

Utilization of Clinical Evaluation Reports in Japan's Medical Device Approvals: Insights from Review Data on Approved Devices.

Therapeutic innovation & regulatory science·2026

Related Experiment Video

Updated: Sep 18, 2025

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
07:47

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

4.2K

Precision Oncology Framework Using Circulating Tumor Cells.

Fumihiko Kakizaki1, Kyoichi Oshiro2, Yuya Enoki1,3

  • 1Department of Personalized Cancer Medicine, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-Ku, Kyoto 606-8507, Japan.

International Journal of Molecular Sciences
|June 26, 2025
PubMed
Summary

Circulating tumor cells (CTCs) are powerful biomarkers for precision oncology. These cells offer insights into cancer progression and treatment response, potentially outperforming traditional markers.

Keywords:
CTCbreast cancercolorectal cancerctDNAprecision oncology

More Related Videos

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization
10:12

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Published on: May 15, 2018

9.1K
Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

16.0K

Related Experiment Videos

Last Updated: Sep 18, 2025

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
07:47

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

4.2K
Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization
10:12

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Published on: May 15, 2018

9.1K
Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

16.0K

Area of Science:

  • Oncology and Molecular Diagnostics

Background:

  • Circulating tumor cells (CTCs) are key biomarkers in precision oncology.
  • CTCs provide prognostic information during various cancer therapies.
  • Tumor heterogeneity in CTCs presents challenges, especially with emerging drug resistance.

Purpose of the Study:

  • To highlight the potential of CTCs in refining cancer diagnoses and personalizing treatments.
  • To discuss the role of CTCs in monitoring treatment response and prognosis.
  • To explore the clinical utility and implementation of CTC assays.

Main Methods:

  • Review of existing technologies for CTC isolation and analysis.
  • Comparison of CTC assays with circulating tumor DNA (ctDNA) tests.
  • Evaluation of CTCs as potential tumor markers in colorectal and breast cancer.

Main Results:

  • CTC assays are reliable prognostic indicators, even during therapy.
  • CTCs reflect tumor progression, while ctDNA correlates with tumor burden.
  • CTC tests show promise as alternatives or complements to conventional tumor markers like CEA, CA19-9, and CA15-3.

Conclusions:

  • Dynamic CTC analysis offers valuable insights into treatment efficacy and patient prognosis.
  • Combined analysis of CTCs and ctDNA may provide complementary prognostic information.
  • Integrating CTC tests into routine blood panels is a rational and promising strategy for improved cancer management.