Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis.

Arthritis care & research·2026
Same author

Refining thrombotic risk in membranous lupus nephritis: is anti-C1q the missing link?

Journal of thrombosis and haemostasis : JTH·2026
Same author

Reply.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

New Hidradenitis Suppurativa in Children: Influence of Neighborhood Socioeconomic Status.

Pediatric dermatology·2026
Same author

Enpatoran, a Toll-like receptor 7/8 inhibitor, in moderate-to-severe systemic lupus erythematosus: findings from Cohort B of a multicentre, international, double-blind, placebo-controlled dose-finding phase 2 trial.

Lancet (London, England)·2026
Same author

Efficacy and safety of enpatoran, a Toll-like receptor 7/8 inhibitor, in patients with skin manifestations of cutaneous lupus erythematosus or systemic lupus erythematosus: findings from Cohort A of a multicentre, international, double-blind, placebo-controlled, dose-finding phase 2 trial.

The Lancet. Rheumatology·2026
Same journal

Understanding the burden of orofacial involvement and patient treatment preferences in systemic sclerosis: results from a large international survey.

Arthritis care & research·2026
Same journal

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis.

Arthritis care & research·2026
Same journal

Associations Between Social Risk Factors and Acute Care Use Among Patients with Rheumatic Conditions.

Arthritis care & research·2026
Same journal

Engagement Patterns with an AI Health Coach for Systemic Sclerosis Self-Management: A Mixed Methods Study.

Arthritis care & research·2026
Same journal

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns.

Arthritis care & research·2026
Same journal

Determinants of body mass index in early systemic sclerosis: implications for nutritional risk stratification.

Arthritis care & research·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.6K

Measuring Frailty in Systemic Lupus Erythematosus.

Patricia Katz1, Maria Dall'Era1, Laura Plantinga1

  • 1University of California San Francisco, San Francisco, California.

Arthritis Care & Research
|December 9, 2024
PubMed
Summary
This summary is machine-generated.

Different frailty measures in systemic lupus erythematosus (SLE) show varying agreement but generally predict poor health outcomes. The Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) demonstrated the most consistent associations with health outcomes in SLE patients.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.8K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.8K

Related Experiment Videos

Last Updated: Jun 12, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.6K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.8K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.8K

Area of Science:

  • Rheumatology and Gerontology
  • Clinical Epidemiology

Background:

  • Frailty is increasingly recognized as a significant factor in systemic lupus erythematosus (SLE).
  • Multiple instruments exist to assess frailty, but their agreement and predictive value in SLE are not fully understood.

Purpose of the Study:

  • To evaluate the agreement among different frailty measures in SLE patients.
  • To determine the association of each frailty measure with cross-sectional and longitudinal health outcomes.

Main Methods:

  • Utilized data from the California Lupus Epidemiology Study.
  • Assessed frailty using Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI), Short Physical Performance Battery (SPPB), and Fatigue, Resistance, Ambulation, Illness, and Loss of Weight (FRAIL) scale.
  • Patient-Reported Outcomes Measurement Information System Physical Function 10a (PF) was used as a proxy; statistical analyses included regression and Cox proportional hazards models.

Main Results:

  • Prevalence of frailty varied significantly across measures (10.8%–45.9%), with slight to substantial agreement (k=0.17–0.63).
  • Most frailty measures correlated with cross-sectional and longitudinal health outcomes, except for SPPB.
  • SLICC-FI showed the most consistent associations, followed by FRAIL and PF, linking frailty to hospitalization, disability, and cognitive impairment.

Conclusions:

  • Multiple frailty assessment tools can identify patients at risk for adverse health outcomes in SLE.
  • The choice of frailty measure should consider its intended application, simplicity, and ease of implementation.