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Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
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Probiotic-Based Mineralized Living Materials to Produce Antimicrobial Yogurts
Gloria B Ramírez-Rodríguez1, Laura Sabio2, Laura Cerezo-Collado1
1Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. de Fuente Nueva, s/n, Granada, 18071, Spain.
Advanced Healthcare Materials
|December 9, 2024
Summary
Researchers created hybrid living materials by mineralizing probiotics within collagen. This protects bacteria for oral delivery and enhances their antibacterial activity, offering new possibilities for healthcare and food applications.
Area of Science:
- Biomaterials Engineering
- Microbiology
- Cellular Biology
Background:
- Cellular mineralization enhances resilience to stress.
- Probiotics require protection for effective oral delivery.
- Existing delivery methods have limitations.
Purpose of the Study:
- To develop hybrid living materials (HLMs) for enhanced probiotic oral delivery.
- To protect probiotics using mineralized collagen matrices.
- To investigate the viability and functionality of encapsulated probiotics.
Main Methods:
- Simultaneous self-assembly and mineralization of collagen fibrils around probiotics (Lactobacillus acidophilus).
- Development of bulk and single-cell encapsulation via apatite nanofilm coating.
- Assessment of HLM metabolic activity, yogurt fermentation, and antibacterial properties against Pseudomonas aeruginosa and Staphylococcus aureus.
- Evaluation of HLM protection in simulated gastric fluid.
Main Results:
- Probiotics were successfully integrated into mineralized collagen matrices (HLMs).
- Single-cell encapsulation with apatite nanofilms reinforced probiotic viability and activity.
- HLMs demonstrated metabolic activity, fermented milk into yogurt, and exhibited antibacterial properties.
- HLMs provided significant protection to probiotics in simulated gastrointestinal conditions.
Conclusions:
- Hybrid living materials offer a novel strategy for robust probiotic oral delivery.
- Mineralized collagen matrices enhance probiotic resilience and functionality.
- These HLMs have potential applications in advanced healthcare materials and antimicrobial probiotic foods.
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