Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

15.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.3K
Nuclear Transmutation03:20

Nuclear Transmutation

17.4K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
17.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reirradiation for recurrent head and neck squamous cell carcinoma: international expert consensus recommendations endorsed by the Reirradiation Collaborative Group, the European Society for Radiotherapy and Oncology Reirradiation Focus Group, and the American Society for Radiation Oncology.

The Lancet. Oncology·2026
Same author

Biologically Effective Dose-Optimized Multi-Intensity-Modulated Proton Therapy: A Biologically Comparable Alternative to Proton Arc Therapy.

International journal of particle therapy·2026
Same author

Proton-Based Chemoradiation With Conventional Fractionation and Systemic Therapy for Failure.

International journal of radiation oncology, biology, physics·2026
Same author

Spread-Out Bragg Peak FLASH Radiotherapy for Head and Neck Reirradiation: A Treatment Planning Study.

International journal of particle therapy·2026
Same author

A Randomized Phase II Trial of Hypo-fractionated Intensity-Modulated Radiation Therapy (IMRT) Utilizing 2.5 Gy/Fraction Versus Standard- Fractionated IMRT, Concurrent With Carboplatin/Paclitaxel and Followed by Consolidation Durvalumab, for Subjects With Stage III Non-Small Cell Lung Cancer.

Clinical lung cancer·2026
Same author

Experimental characterization of proton minibeam therapy delivery under FLASH dose-rate conditions.

Scientific reports·2026

Related Experiment Video

Updated: Jun 5, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K

Multi-IMPT: a biologically equivalent approach to proton ARC therapy.

Nimita Shinde1, Yanan Zhu1, Wei Wang1

  • 1Department of Radiation Oncology, University of Kansas Medical Center, USA.

Arxiv
|December 9, 2024
PubMed
Summary

A novel multiple intensity-modulated proton therapy (multi-IMPT) approach achieves plan quality comparable to proton spot-scanning arc therapy (ARC). This method offers a viable alternative for efficient and effective proton therapy delivery, demonstrating potential for improved organ-at-risk sparing.

Keywords:
biologically effective dose (BED)proton arc therapy

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.7K
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.5K

Related Experiment Videos

Last Updated: Jun 5, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.7K
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.5K

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Cancer Treatment

Background:

  • Proton spot-scanning arc therapy (ARC) offers improved target dose conformity over standard intensity-modulated proton therapy (IMPT).
  • Efficient ARC delivery is hindered by frequent energy changes during continuous gantry rotation.
  • This study introduces a method to achieve ARC-equivalent plan quality using multiple IMPT (multi-IMPT) plans.

Purpose of the Study:

  • To propose and evaluate a novel multi-IMPT method for delivering biologically effective dose (BED) equivalent to ARC.
  • To compare the plan quality of the proposed multi-IMPT approach with conventional ARC therapy.

Main Methods:

  • The multi-IMPT method uses distinct subsets of beam angles per fraction.
  • Biologically effective dose (BED) for organs at risk (OAR) and physical dose for targets are optimized per fraction.
  • Inverse optimization was performed using iterative convex relaxation and alternating direction method of multipliers.

Main Results:

  • Multi-IMPT demonstrated comparable plan quality to ARC across various clinical cases.
  • The multi-IMPT approach showed improved OAR sparing and target dose coverage in a prostate cancer example.
  • Dose distributions were similar for lung cancer, slightly inferior for brain cases, and showed better coverage with slightly higher OAR BED for head-and-neck cases.

Conclusions:

  • A multi-IMPT approach can effectively deliver ARC-equivalent plan quality.
  • This method presents a promising strategy for overcoming the delivery challenges of ARC therapy.
  • The proposed technique may enhance treatment efficiency and therapeutic outcomes in proton therapy.