Renal Function as a Predictor of Mortality and Functional Outcomes in Acute Stroke: A Prospective Study

Area of Science:

• Nephrology
• Neurology
• Cardiovascular Medicine

Background:

• Stroke remains a leading global cause of death and disability.
• Identifying modifiable factors influencing stroke outcomes is critical for patient management.
• Renal function is increasingly recognized as a potential determinant of stroke prognosis.

Purpose of the Study:

• To investigate the association between renal function markers (serum creatinine and eGFR) and mortality in acute stroke patients in India.
• To evaluate the impact of renal function on functional outcomes post-stroke.
• To compare renal function between ischemic and hemorrhagic stroke subtypes.

Main Methods:

• Prospective observational study of 104 acute stroke patients.
• Assessment of renal function using serum creatinine and estimated glomerular filtration rate (eGFR).
• Functional outcomes measured by Modified Rankin Scale (mRS); mortality analyzed using logistic regression.

Main Results:

• Decreased eGFR and elevated serum creatinine were significantly linked to poorer stroke outcomes.
• Hemorrhagic stroke patients exhibited lower eGFR and higher mortality rates compared to ischemic stroke patients.
• Established predictive thresholds for serum creatinine (1.495 mg/dL) and eGFR (48.5 mL/min) for mortality risk.

Conclusions:

• Serum creatinine and eGFR are significant predictors of mortality and functional outcomes in acute stroke.
• Poorer renal function is associated with higher mortality in hemorrhagic stroke.
• Routine assessment of renal function is recommended for optimizing stroke patient care and prognosis.