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Updated: Jun 5, 2025
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
The Effects of Remimazolam versus Propofol on Endovascular Thrombectomy for Acute Ischemic Stroke: Study Protocol for
Lijuan Fu1, Rui Zhou2, Wencai Jiang1
1Department of Anesthesiology, Deyang People's Hospital, Deyang City, Sichuan Province, People's Republic of China.
Background:
While general anesthesia has been widely used in endovascular thrombectomy for acute ischemic stroke (AIS), the optimal anesthesia medication for hemodynamic management remains unclear.
Purpose:
To compare the effects of remimazolam and propofol on endovascular thrombectomy for AIS.
Methods:
This study is a single-center, double-blind and randomized controlled trial. Eligible patients will be randomly allocated into the remimazolam group and propofol group. Remimazolam and propofol will be administered to induce and maintain anesthesia respectively. The primary outcome is the incidence of intraoperative hypotension. The secondary outcomes include frequency of hypotension, the largest difference value of mean arterial pressure (MAP), dosage of vasopressors, extubation time, operation time, modified thrombolysis in cerebral infarction (mTICI) level, National Institutes of Health Stroke Scale (NIHSS) score and modified Rankin scale (mRS) score.
Conclusion:
This study evaluates the influences of remimazolam versus propofol on endovascular therapy for AIS patients. Results of this study are expected to provide more evidence of the choice of anesthetics in this kind of operation.
Trial Registration:
This study has been registered at the Chinese Clinical Trial Registry (ChiCTR2300076880).
Insights
This randomized trial compares remimazolam and propofol for anesthesia during endovascular thrombectomy in acute ischemic stroke (AIS) patients. It aims to determine the optimal anesthetic for hemodynamic stability during this critical procedure.
Area of Science:
- Neuroscience
- Anesthesiology
- Cardiovascular Medicine
Background:
- Anesthesia choice for endovascular thrombectomy in acute ischemic stroke (AIS) impacts hemodynamic management.
- Optimal anesthetic agents for maintaining hemodynamic stability during AIS interventions are not well-defined.
Purpose of the Study:
- To compare the efficacy and safety of remimazolam versus propofol for anesthesia during endovascular thrombectomy in AIS patients.
- To evaluate the impact of remimazolam and propofol on hemodynamic parameters and clinical outcomes.
Main Methods:
- A single-center, double-blind, randomized controlled trial involving patients undergoing endovascular thrombectomy for AIS.
- Patients were randomized to receive either remimazolam or propofol for anesthesia induction and maintenance.
- Primary outcome: incidence of intraoperative hypotension. Secondary outcomes: hypotension frequency, mean arterial pressure (MAP) variability, vasopressor use, extubation time, operation time, mTICI, NIHSS, and mRS scores.
Main Results:
- This section is to be filled upon study completion.
Conclusions:
- This study will provide critical evidence for selecting anesthetics during endovascular thrombectomy for AIS.
- Findings are expected to guide clinical practice in optimizing anesthetic management for improved patient outcomes.
