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Related Concept Videos

Cerebral Hemispheres01:05

Cerebral Hemispheres

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The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
297

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Heterogeneous Brain Dynamics Between Acute Cerebellar and Brainstem Infarction.

Mingqing Jiang1,2, Feng Xu3, Ziye Lei4

  • 1Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.

Cerebellum (London, England)
|December 9, 2024
PubMed
Summary

Brainstem and cerebellar infarctions alter brain dynamics, impacting cognitive function. EEG microstate analysis reveals distinct patterns in these patients, correlating with cognitive deficits and symptoms like dizziness.

Keywords:
Brainstem infarctionCerebellar infarctionDizzinessEEG microstateVertigo

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Cognitive Science

Background:

  • Brainstem and cerebellar infarctions are associated with neurological deficits.
  • Understanding the underlying brain dynamics is crucial for diagnosing and managing cognitive impairments.

Purpose of the Study:

  • To investigate alterations in brain dynamics using electroencephalogram (EEG) microstate analysis in patients with acute cerebellar infarction (CI) and acute brainstem infarction (BsI).
  • To explore the relationship between these brain dynamic changes and cognitive function.
  • To differentiate clinical presentations like dizziness and vertigo based on microstate patterns.

Main Methods:

  • Recruited 37 CI patients, 32 BsI patients, and 40 healthy controls (HC).
  • Recorded resting-state EEG data and performed microstate analysis.
  • Assessed cognitive function using a battery of neuropsychological tests including MMSE, MoCA, BNT, Digitspan, and SDMT.

Main Results:

  • BsI patients showed decreased transitions from Microstate A (MsA) and MsD to MsC, and increased transitions from MsA to MsD and MsD to MsB compared to HC.
  • CI patients exhibited increased transitions from MsA and MsD to MsC, and decreased transitions from MsD to MsB.
  • Microstate changes significantly correlated with cognitive performance in both CI and BsI groups.
  • Specific microstate alterations differentiated dizziness from vertigo in CI patients and pontine from medullary infarctions in BsI patients.

Conclusions:

  • Altered brain dynamics, as measured by EEG microstates, are evident in patients with CI and BsI.
  • These dynamic disturbances are linked to cognitive impairment in these patient populations.
  • Microstate analysis shows potential as a clinical tool for differentiating symptoms and aiding diagnosis in stroke patients.