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Related Concept Videos

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Related Experiment Video

Updated: Jun 5, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Probiotic Supplements Benefit Psoriasis Therapy Rather Than Affecting Disease Risk: Evidence from NHANES

Yajia Li1,2, Xiao Liu2,3, Ziqin Cao4,5

  • 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.

Probiotics and Antimicrobial Proteins
|December 9, 2024
PubMed
Summary
This summary is machine-generated.

Probiotic supplements do not reduce psoriasis risk but significantly improve disease severity. A large study and meta-analysis show probiotics lower Psoriasis Area and Severity Index (PASI) scores and enhance treatment responses.

Keywords:
Machine-learningMetaNHANESProbioticPsoriasis

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Area of Science:

  • Dermatology and Gastroenterology
  • Microbiome Research
  • Nutritional Science

Background:

  • Psoriasis is a chronic inflammatory skin condition with significant impact on quality of life.
  • The role of gut microbiota and probiotic supplementation in managing psoriasis is an area of ongoing research.
  • Existing evidence on probiotic efficacy in psoriasis requires further investigation, particularly regarding disease risk and severity.

Purpose of the Study:

  • To investigate the association between probiotic intake and the risk of developing psoriasis.
  • To evaluate the impact of probiotic supplementation on psoriasis severity, quality of life, and inflammatory markers.
  • To synthesize existing evidence through a meta-analysis to provide robust conclusions on probiotic efficacy.

Main Methods:

  • Analysis of a large cohort (n=21,942) from the National Health and Nutrition Examination Survey (NHANES) using machine learning techniques.
  • Meta-analysis of studies assessing probiotic effects on Psoriasis Area and Severity Index (PASI) scores, quality of life, and inflammatory markers.
  • Statistical analysis using odds ratios (ORs) with 95% confidence intervals (CIs) for dichotomous data.

Main Results:

  • NHANES data analysis did not find a significant link between probiotic consumption and reduced psoriasis risk.
  • Meta-analysis revealed that probiotic supplementation significantly reduces PASI scores and improves PASI 75 and clearance rates.
  • Probiotics demonstrated a reduction in inflammatory markers, with quality of life improvements noted in post-treatment data.

Conclusions:

  • Probiotic supplementation shows a significant therapeutic benefit in reducing psoriasis severity.
  • Probiotics do not appear to lower the risk of developing psoriasis based on current evidence.
  • Further research may explore specific probiotic strains and mechanisms for psoriasis management.