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Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT

Zhuangzhuang Shi1, Min Li2, Chen Zhang3,4,5

  • 1Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Gut
|December 9, 2024
PubMed
Abstract

Insights

Reduced Faecalibacterium prausnitzii in the gut microbiome is linked to poorer outcomes in natural killer/T-cell lymphoma (NKTCL). Restoring this bacterium may offer a novel therapeutic strategy for NKTCL patients.

Area of Science:

  • Oncology
  • Microbiome research
  • Immunology

Background:

  • Natural killer/T-cell lymphoma (NKTCL) is an aggressive cancer with poor prognosis.
  • Understanding factors influencing NKTCL outcomes is crucial.

Purpose of the Study:

  • To characterize gut microbiota in NKTCL patients.
  • To identify potential probiotic targets for NKTCL treatment.

Main Methods:

  • Shotgun metagenomic sequencing of gut microbiota in Chinese and Korean NKTCL cohorts.
  • Analysis of associations between microbial species and patient survival.
  • In vivo and in vitro studies to assess antitumour effects of F. prausnitzii and its metabolite, butyrate.

Main Results:

  • Significant gut microbiota dysbiosis observed in NKTCL patients, with reduced Faecalibacterium prausnitzii correlating with shorter survival.
  • F. prausnitzii demonstrated antitumour properties in NKTCL models, inhibiting cancer cell growth.
  • Butyrate, a metabolite of F. prausnitzii, suppressed NKTCL progression by inhibiting the JAK-STAT pathway via enhanced histone acetylation and increased SOCS1 expression.

Conclusions:

  • NKTCL exhibits a distinct gut microbiota profile.
  • Faecalibacterium prausnitzii and its metabolite butyrate show therapeutic potential for NKTCL.
Keywords:
BUTYRATEINTESTINAL MICROBIOLOGYLYMPHOMAPROBIOTICS

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