Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nucleic acids

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Nucleic Acids and Nucleotides

Nucleic Acids and Nucleotides

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Extracellularly Activated Logic-Gated DNA Nanodevice for Molecular Transport via Reprogrammed Transferrin Receptor Trafficking.

Small (Weinheim an der Bergstrasse, Germany)·2025

Same author

Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea.

Brain and behavior·2025

Same author

Construction of the Lactone-Bridged Scaffold of Alstoscholactine through an Acid-Catalyzed Prins Cyclization/Lactonization Cascade.

Organic letters·2025

Same author

Structuring 3D-printed polypropylene composites with vertically aligned mesophase pitch-based carbon fibers for enhanced through-plane thermal conductivity and mechanical properties.

Materials horizons·2025

Same author

Skeletal Muscle Segmentation at the Level of the Third Lumbar Vertebra (L3) in Low-Dose Computed Tomography: A Lightweight Algorithm.

Tomography (Ann Arbor, Mich.)·2024

Same author

A comprehensive review on the dynamics of protein kinase CK2 in cancer development and optimizing therapeutic strategies.

International journal of biological macromolecules·2024

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

A Polyaniline-based Sensor of Nucleic Acids

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Framework Nucleic Acids: Innovative Tools for Cellular Sensing and Therapeutics.

Yihan Zhang¹, Yuting Li¹, Bowen Fang¹

¹School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.

Chembiochem : a European Journal of Chemical Biology

|December 9, 2024

Summary

Framework nucleic acids (FNAs) show promise as biomaterials for cellular sensing and disease treatment. Their programmability and design capabilities offer potential for personalized medicine and advanced therapies.

Keywords:

Advanced Therapies Cell Behavior Regulation DNA Biosensors DNA Nanotechnology Framework Nucleic Acids

More Related Videos

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Published on: June 17, 2022

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Related Experiment Videos

Last Updated: Jul 6, 2026

A Polyaniline-based Sensor of Nucleic Acids

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Published on: June 17, 2022

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Area of Science:

Biomaterials Science
Molecular Biology
Nanotechnology

Background:

Framework nucleic acids (FNAs) are emerging biomaterials with high programmability and structural diversity.
FNAs offer precise molecular design capabilities, making them suitable for biomedical applications.

Purpose of the Study:

To review the applications of FNAs in cellular sensing and disease treatment.
To discuss the potential of FNAs in personalized medicine, precision diagnostics, and advanced therapies.

Main Methods:

Systematic review of existing literature on FNA applications.
Analysis of FNA capabilities in recognizing cellular targets and delivering therapeutic interventions.

Main Results:

FNAs demonstrate precise recognition of extracellular tumor microenvironment, cell membrane proteins, and intracellular biomarkers.
FNAs show potential in drug delivery, cell behavior regulation, and immunomodulation for disease treatment.

Conclusions:

FNAs hold significant potential for breakthroughs in biomedical innovation and clinical translation.
The unique properties of FNAs position them for advancements in personalized medicine and precision diagnostics.