Early experience with the Aristotle Colossus 0.035' macrowire for mechanical thrombectomy in 30 consecutive cases

Area of Science:

• Endovascular therapy
• Neurointerventional surgery
• Vascular access devices

Background:

• Large-bore aspiration catheters are effective for thrombus removal in mechanical thrombectomy.
• Catheter-to-microwire step-off and distal navigation remain challenges in thrombectomy procedures.
• A novel 0.035-inch macrowire (Aristotle 35 Colossus Guidewire) may address these navigation challenges.

Purpose of the Study:

• To evaluate the early clinical experience with the Aristotle 35 Colossus Guidewire in mechanical thrombectomy.
• To assess the safety and efficacy of this new macrowire in complex thrombectomy cases.

Main Methods:

• A prospectively maintained database was analyzed for mechanical thrombectomy cases utilizing the 0.035-inch macrowire with 0.035-inch aspiration catheters.
• Thirty consecutive cases were identified and reviewed.

Main Results:

• The Aristotle 35 Colossus Guidewire was successfully used in 30 mechanical thrombectomy cases.
• Thrombus ingestion was achieved with TICI 2C/3 reperfusion in 87% of cases.
• No wire-related perforations or vessel dissections were reported, indicating a favorable safety profile.

Conclusions:

• The 0.035-inch Colossus macrowire may offer advantages in mechanical thrombectomy by potentially reducing ledge effect and the need to cross thrombus.
• Further comparative studies are warranted to evaluate this macrowire against existing microwires across diverse anatomical presentations.