Changes in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation.
Johannes Achtzehn1,2, Friederike Grospietsch1, Alexandra Horn1
1Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Human Brain Mapping
|December 10, 2024
Summary
Subthalamic deep brain stimulation (DBS) in Parkinson's disease (PD) alters brain connectivity, impairing inhibitory control during complex tasks. This functional network modulation affects motor and cognitive functions in PD patients.
Area of Science:
- Neuroscience
- Neurology
- Biomedical Engineering
Background:
- Subthalamic deep brain stimulation (DBS) in Parkinson's disease (PD) impacts motor and cognitive functions, particularly in high-conflict situations.
- Understanding the neural mechanisms underlying these effects is crucial for optimizing PD treatment.
Purpose of the Study:
- To investigate the relationship between resting-state functional connectivity (RSFC) changes induced by STN-DBS and the modulation of response and movement inhibition.
- To explore how STN-DBS affects inhibitory control in a visuomotor task with high conflict in PD patients.
Main Methods:
- 14 PD patients underwent a visuomotor task with subthalamic nucleus (STN) DBS ON and OFF.
- Resting-state functional MRI (rs-fMRI) data were acquired during both DBS conditions.
- Link-wise network-based statistics were used to analyze changes in RSFC and their correlation with behavioral outcomes.
Main Results:
- STN-DBS modulated RSFC, correlating with behavioral changes.
- Reduced reaction time adaptation and increased movement velocity were observed with DBS ON.
- Attenuated connectivity between motor cortical areas, basal ganglia, and thalamus was linked to reaction time changes.
- Increased pallido-thalamic connectivity correlated with higher movement velocity.
Conclusions:
- STN-DBS-induced decoupling of the motor cortico-basal ganglia network contributes to impaired inhibitory control in PD.
- These findings highlight the role of functional network modulation by DBS in PD.
- The study suggests specific connectivity changes underlie behavioral deficits during STN-DBS in Parkinson's disease.
Keywords:
Parkinson's diseasecognitive controldeep brain stimulationfunctional connectivitysubthalamic nucleusMore Related Videos
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