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Updated: Jun 5, 2025
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Molecular acceptor engineering to precisely design a NIR type I photosensitizer for efficient PDT-based synergistic
Ziqi Zou1, Yili Xie2, Jiaxing Wan1
1Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China. tjwen820@126.com.
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Molecular design plays a crucial role in regulating the photophysical properties and photodynamic therapy (PDT) performance of photosensitizers (PSs); however, realizing PDT-based synergistic therapy based on sole PSs is still rarely reported. Herein, three near-infrared red type I PSs (named TP1, TP2, and TP3) were synthesized by adjusting their electron acceptors. The results demonstrated that these PSs exhibited aggregation-enhanced reactive oxygen species (ROS) generation efficiency and cyano groups on PSs can reduce ROS generation in solution while achieving efficient PDT-based synergistic therapy in cells via glutathione depletion.
