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Roles of BMI in mediating the causal effect of obstructive sleep apnea on psoriasis: a two-step mendelian

Hanyu Wang1, Bowen Yang1,2, Xiaoyu Zeng1

  • 1Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Archives of Dermatological Research
|December 10, 2024
PubMed

Insights

Genetically predicted obstructive sleep apnea (OSA) causally increases psoriasis risk. Body mass index (BMI) may mediate this link, suggesting potential therapeutic targets for managing psoriasis in OSA patients.

Area of Science:

  • Genetics and Epidemiology
  • Sleep Medicine
  • Dermatology

Background:

  • Observational studies suggest a link between obstructive sleep apnea (OSA) and psoriasis.
  • The causal nature of this association requires further investigation.

Purpose of the Study:

  • To investigate the potential causal relationship between obstructive sleep apnea (OSA) and psoriasis using Mendelian Randomization (MR).
  • To explore the mediating role of Body Mass Index (BMI) in the OSA-psoriasis association.

Main Methods:

  • Utilized two-sample and two-step Mendelian Randomization (MR) analysis.
  • Employed Inverse-Variance Weighted (IVW) as the primary method, supplemented by sensitivity analyses.
  • Extracted OSA-associated SNPs from FinnGen and psoriasis GWAS data from the IEU GWAS database.

Main Results:

  • Genetically predicted OSA showed a significant positive causal association with psoriasis (OR=1.26, p<0.001).
  • No significant causal effect of psoriasis on OSA was detected (p>0.05).
  • Two-step MR indicated BMI mediates approximately 23% of the effect of OSA on psoriasis.

Conclusions:

  • Provides evidence supporting a causal link between genetically predicted OSA and an increased risk of psoriasis.
  • Suggests that BMI may act as a significant mediator in the pathway from OSA to psoriasis development.
Keywords:
BMICausal associationGWASMendelian randomizationObstructive sleep apneaPsoriasis

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