Related Experiment Video
Updated: Jun 5, 2025
09:49
Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
Published on: May 10, 2024
673
Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled
Maleea D Holbert1,2, Fiona Wood3,4, Andrew J A Holland5,6
1School of Nursing and Midwifery, Griffith University, Nathan Campus, South Brisbane, QLD, Australia.
Plos One
|December 10, 2024
Summary
Negative pressure wound therapy (NPWT) aids pediatric burn healing but isn't standard. The INPREP trial will implement and assess NPWT in Australian hospitals to improve its adoption and clinical outcomes for pediatric burns.
Area of Science:
- Pediatric Burn Care
- Wound Healing Technologies
- Clinical Implementation Science
Background:
- Negative pressure wound therapy (NPWT) accelerates re-epithelialization in pediatric burns.
- NPWT is not yet a routine primary dressing strategy for pediatric burns.
- The INPREP trial addresses this gap by implementing and evaluating NPWT in major pediatric hospitals.
Purpose of the Study:
- To implement and evaluate the impact of adjunctive NPWT in acute pediatric burn care.
- To assess the effectiveness of the INPREP toolkit, comprising co-designed implementation strategies and resources.
- To measure both implementation outcomes (adoption, feasibility) and clinical outcomes (healing time, scarring).
Main Methods:
- Multi-center, prospective, stepped-wedge cluster randomized controlled trial.
- Involves pediatric burn patients across four Australian tertiary pediatric hospitals.
- Hybrid Type III design evaluating NPWT implementation alongside the INPREP toolkit.
Main Results:
- Primary outcome is treatment adoption rate (proportion of eligible patients receiving NPWT).
- Secondary outcomes include days to re-epithelialization, scar management, and skin grafting needs.
- Implementation outcomes like appropriateness, acceptability, and sustainability will also be assessed.
Conclusions:
- The INPREP trial protocol outlines a hybrid Type III stepped-wedge cluster randomized controlled trial for adjunctive NPWT in pediatric burns.
- Successful NPWT implementation using the INPREP toolkit is expected to be generalizable across Australia.
- Findings will inform international pediatric burn care practices and promote wider NPWT adoption.
More Related Videos
Related Concept Videos
01:22Burn Injuries
2.4K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.4K
01:23Mechanical Ventilation III: Noninvasive Ventilation
79
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
79
01:29Acute Respiratory Failure-V
123
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
123
01:29Suctioning the Nasopharyngeal Airway
281
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
281
01:26Flail Chest-II
160
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
Assessment:
1. Clinical Evaluation:
History:
160
01:23Mechanical Ventilation II: Invasive Ventilation
110
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
110