Related Experiment Video
Updated: Jun 5, 2025

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Factors affecting target INR levels in homebound and ambulatory patients who use warfarin
Ozge Tuncer1, Ayca Asma Sakalli1, Mustafa Ozan Gursoy2
1Department of Family Medicine, Health Sciences University, Izmir Bozyaka Training and Research Hospital, Izmir.
Objective:
To investigate the rates of reaching target international normalised ratio levels and the factors affecting these rates in patients undergoing warfarin therapy.
Methods:
The prospective cross-sectional study was conducted between 16.08.2023 and 16.11.2023 at Izmir Bozyaka Training and Research Hospital and comprised patients of either gender who had been reciving warfarin therapy for at least 6 months. Those who were under the care of Home Health Services were in group A, while those being followed up at the cardiology outpatient clinic were in group B. All the patients had been receiving regular monitoring for international normalised ratio. Data was collected using a self-designed 41-item questionnaire. Data was analysed using SPSS 27.
Results:
Of the 200 patients, 100(50%) were in each of the 2 groups. The overall mean age of the sample was 69.54±12.70 years. There were 131(65.5%) females, 108(54%) had international normalised ratio level within the target range, 101(50.5%) stated they had received education about warfarin, 120(60%) were aware of the side effects, and 81(40.5%) indicated they experienced complications while using warfarin. Group A patients received more education/information about warfarin, and warfarin-related complications were few in such patients (p<0.05).
Conclusion:
International normalised ratio monitoring among patients under the care of Home Healthcare Service was more reliably and effective compared to cardiology inpatients.
Related Concept Videos
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Factors Affecting Drug Response: Overview
Therapeutic Index
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Factors Affecting Drug Distribution: Miscellaneous Factors
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...

