2D Materials-Based Field-Effect Transistor Biosensors for Healthcare
Jingwei Li1,2, Leonardo Nicholas Adi Wijaya2, Dong Wook Jang2
1Department of Chemical and Biological Engineering, William Mong Institute of Nano Science and Technology and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, P. R. China.
2D field-effect transistor (FET) biosensors offer rapid, ultrasensitive detection for point-of-care diagnostics. This review explores their advancements, challenges, and future potential in healthcare and environmental monitoring.
Area of Science:
- Materials Science
- Biotechnology
- Nanotechnology
Background:
- The demand for accurate point-of-care (POC) diagnostic tools drives biosensor technology evolution.
- 2D materials-based field-effect transistor (2D FET) biosensors provide label-free, rapid, and ultrasensitive detection, aligning with current trends.
Purpose of the Study:
- To review the progress, challenges, and future prospects of 2D FET biosensors.
- To highlight the impact of 2D materials' properties and scalable synthesis on FET biosensor performance.
Main Methods:
- Review of recent advancements in 2D FET biosensor technology.
- Investigation of applications in disease diagnosis, management, and environmental monitoring.
- Analysis of integration with flexible electronics.
Main Results:
- 2D FET biosensors demonstrate promising capabilities in laboratory trials for various applications.
- Scalable synthesis of 2D materials enhances manufacturing and performance.
- Integration into flexible electronics is advancing prototype development.
Conclusions:
- Challenges in sensitivity, stability, and scalability hinder widespread commercialization.
- Strategies to overcome these challenges are discussed.
- Future implications include smart, sustainable POC biosensors for improved healthcare.
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