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Updated: Jun 5, 2025
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Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
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Dysphagia in progressive supranuclear palsy: A scoping review
Éadaoin Flynn1,2, Julie Regan1, Julia Glinzer3
1Department of Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland.
Clinical Parkinsonism & Related Disorders
|December 11, 2024
Summary
Dysphagia in progressive supranuclear palsy (PSP) primarily involves oral phase difficulties. Current research lacks detail on PSP subtypes and the impact of dysphagia on quality of life.
Area of Science:
- Neurology
- Swallowing Disorders
- Geriatric Medicine
Background:
- Progressive supranuclear palsy (PSP) is a common atypical parkinsonian syndrome.
- Early-onset dysphagia in PSP leads to malnutrition, dehydration, and aspiration pneumonia, impacting quality of life and survival.
- Research on dysphagia characteristics and impact in PSP is limited.
Purpose of the Study:
- To characterize dysphagia in PSP.
- To explore dysphagia variations across PSP subtypes.
- To identify diagnostic methods and assess dysphagia's impact on quality of life in PSP.
Main Methods:
- Scoping review conducted following JBI methodology.
- Searched six electronic databases.
- Included 20 studies.
Main Results:
- Oral preparatory and oral phase difficulties were the most common dysphagia characteristics.
- Dysphagia diagnosis utilized instrumental assessments (65%), patient-reported scales (45%), and clinical swallow evaluations (20%).
- Videofluoroscopy was the most frequent instrumental assessment (46%); data on subtype-specific dysphagia and quality of life impact were scarce.
Conclusions:
- Various methods are employed for dysphagia assessment in PSP.
- Further research is needed to link specific dysphagia characteristics to PSP subtypes.
- Future studies should quantify the impact of dysphagia on quality of life in PSP patients.
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