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Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities.

Hun Jin Jeong1, Lan Anh P Hoang1, Neeve Chen1

  • 1College of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.

Bioactive Materials
|December 11, 2024
PubMed
Summary

This review highlights the clinical importance of regenerating neglected soft-hard tissue interfaces in the dental and craniofacial systems. Bioengineering approaches using 3D scaffolds offer promising regenerative strategies.

Keywords:
Bioactive scaffoldMulti-tissue interfacePeriodontiumRegenerative engineeringTemporomandibular joint disordersTissue engineeringTissue regeneration

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Craniofacial Biology

Background:

  • Soft-hard tissue interfaces are crucial for load transmission and injury protection, featuring gradient changes in cells and matrix.
  • Musculoskeletal and periodontal interfaces are well-researched regenerative targets.
  • Dental and craniofacial soft-hard tissue interfaces remain underexplored despite their clinical significance.

Purpose of the Study:

  • To discuss the clinical significance of regenerative strategies for neglected soft-hard tissue interfaces in the dental and craniofacial systems.
  • To review bioengineering approaches utilizing 3D scaffolds with spatially controlled bioactivities for interface regeneration.
  • To identify remaining challenges and future perspectives for clinical translation.

Main Methods:

  • Literature review focusing on regenerative strategies for soft-hard tissue interfaces.
  • Analysis of bioengineering approaches, particularly 3D scaffolds with controlled bioactivities.
  • Discussion of clinical translation considerations.

Main Results:

  • The clinical significance of dental and craniofacial soft-hard tissue interfaces is substantial but often overlooked.
  • 3D scaffolds with spatially controlled bioactivities represent a key bioengineering strategy for regeneration.
  • Significant challenges remain in scaffold design, bioactivity control, and clinical translation.

Conclusions:

  • Regenerative strategies for dental and craniofacial soft-hard tissue interfaces are clinically significant and require further development.
  • Bioactive 3D scaffolds show promise but need further research to overcome challenges in clinical translation.
  • Future research should focus on innovative scaffold designs and robust preclinical/clinical validation.