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Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis
Yue Gao1, Siyu Zhang2, Xianhong Zhang1
1State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
Iscience
|December 11, 2024
Summary
Cancer cells reprogram metabolism and epigenetics to proliferate. Metabolites fuel epigenetic changes, impacting tumor immunity and guiding new cancer therapies.
Area of Science:
- Oncology
- Epigenetics
- Cancer Metabolism
Background:
- Cancer arises from genetic mutations, leading to cellular changes like metabolic reprogramming and epigenetic modifications.
- Metabolic reprogramming alters enzyme expression and metabolite levels, crucial for cancer cell survival and proliferation.
- Epigenetic modifications are increasingly recognized for their role in cancer progression, immune evasion, and metabolic alterations.
Purpose of the Study:
- To review the interplay between cancer cell metabolism and epigenetic modifications.
- To elucidate how cancer-derived metabolites contribute to epigenetic remodeling.
- To discuss the influence of epigenetic changes on tumor immunity and therapeutic strategies.
Main Methods:
- Literature review focusing on recent advancements in cancer metabolism and epigenetics.
- Analysis of studies linking metabolic enzymes and metabolites to chromatin modification.
- Synthesis of research on epigenetic impacts on cancer progression and immune response.
Main Results:
- Cancer cell metabolism fuels epigenetic modifications (lactylation, acetylation, succinylation, crotonylation) via metabolites.
- Epigenetic alterations influence cancer cell metabolic reprogramming and immune evasion.
- Targeting metabolic and epigenetic pathways shows promise in cancer therapy.
Conclusions:
- Metabolic reprogramming and epigenetic modifications are central to cancer development and progression.
- Cancer metabolites serve as direct substrates for epigenetic enzymes, linking metabolism and epigenetics.
- Targeting these interconnected pathways offers novel therapeutic avenues for cancer treatment.
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