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Updated: Jun 5, 2025

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Facile in situ synthesis of silver nanoclusters for promoting highly sensitive surface-enhanced Raman scattering
Leixin Hou1, Mi Zhang1, Daofu Liu1
1School of Chemistry and Materials Engineering, Huainan Normal University, Huainan, Anhui, 232000, P. R. China.
Abstract:
We synthesized two novel silver-based nanocluster materials (TOS-Ag4 NCs and TNS-Ag8 NCs) that were used as SERS substrates, combining the powerful adsorption capability and aggregation effect of silver-sulfur clusters to achieve a highly sensitive identification and detection of alkyne-tagged molecules in the Raman-silent region. This work provides new insights for designing novel nanoclusters as SERS substrates displaying ultrahigh sensitive detection of alkyne-tagged molecules.

