Multifunctional Integrated Biosensors Based on Two-Dimensional Field-Effect Transistors

In recent years, field-effect transistor (FET) sensing technology has attracted significant attention owing to its noninvasive, label-free, real-time, and user-friendly detection capabilities. Owing to the large specific surface area, high flexibility, and excellent conductivity of two-dimensional (2D) materials, FET biosensors based on 2D materials have demonstrated unique potential in biomarker analysis and healthcare applications, driving continuous innovation and transformation in the field. Here, we review recent trends in the development of 2D FET biosensors based on key performance metrics and main characteristics, and we also discuss structural designs and modification strategies for biosensing devices utilizing graphene, transition metal dichalcogenides, black phosphorus, and other 2D materials to enhance key performance metrics. Finally, we offer insights into future directions for biosensor advancements, discuss potential improvements, and present new recommendations for practical clinical applications.