Deoxygenative Reduction of 1°, 2° and 3° Amides via In Situ Generated Tungsten Cluster Acting as H-Bonding Donor
Yuzan Liu1, Xiaofang Zhai1,2, Liqing Yang1
1School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, Jiangsu, P. R. China.
Abstract:
A protocol of amide-to-amine transformation that is convenient, mild, and easy to perform is a long-sought goal from the viewpoint of catalysis. Herein, we have utilized easily accessible W(CO)4(NCMe)2 as a precatalyst for the deoxygenative reduction of 1°, 2° and 3° amides under mild conditions. Mechanism studies unraveled that the in situ generated W-cluster is potentially a vital species in activating C═O of amides by providing the H-bonding network during the catalytic cycle. Significantly, this tactic offers a complementary pattern to conventional metal-catalyzed amide deoxygenative reactions with activation of the C═O bond via direct coordination with amide.
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