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Related Experiment Video

Updated: Jun 5, 2025

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Regenerative Nanofat Membrane Development Process.

Nabil Fakih-Gomez1,2, Roshini Manay3, Shahriar Nazari4

  • 1Department of Facial Plastic & Cranio-Maxillo-Facial Surgery, Fakih Hospital, Khaizaran, Lebanon. info@drnabilfakih.com.

Aesthetic Plastic Surgery
|December 11, 2024
PubMed
Summary
This summary is machine-generated.

A novel nanofat-platelet-rich fibrin membrane, combining adipose-derived stem cells and growth factors, significantly improves chronic wound healing. This innovative approach shows high patient satisfaction and no complications across diverse applications.

Keywords:
Adipose-derived stem cellsFat membraneNanofat membranePlatelet-rich fibrinRegenerative medicineWound healing

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Wound Healing Research

Background:

  • Chronic wounds pose significant clinical challenges, often complicated by infection and delayed healing.
  • Conventional treatments frequently prove insufficient, highlighting the need for advanced wound healing strategies.
  • This study explores a novel combination therapy using adipose-derived stem cells (ADSCs) and platelet-rich fibrin (PRF) to improve wound repair.

Purpose of the Study:

  • To introduce and evaluate a novel Nanofat-PRF membrane for enhanced wound healing.
  • To demonstrate the clinical efficacy and safety of this innovative biomaterial.

Main Methods:

  • A Fakih-Manay fat membrane device was used to prepare fat membranes from microfat, creating nanofat.
  • Nanofat was emulsified and combined with PRF to form a uniform, versatile, and suture-friendly Nanofat-PRF membrane.
  • The membrane was applied to 172 patients across various surgical and medical applications.

Main Results:

  • The Nanofat-PRF membrane demonstrated significant improvements in wound healing for diverse conditions, including diabetic foot ulcers, cleft palate repairs, and post-surgical complications.
  • Over a 5-year period (April 2019-April 2024), 172 patients were treated with the membrane.
  • Follow-up (1-16 months) indicated high patient satisfaction, substantial healing enhancement, and no reported complications.

Conclusions:

  • The Nanofat-PRF membrane is a versatile and innovative solution for promoting healing in a wide array of medical and surgical scenarios.
  • This research provides initial evidence for the creation method, clinical effectiveness, and safety of Nanofat-PRF membranes.
  • The study highlights a promising, complication-free approach to advanced wound management.