Real-World Usage of CaHA-CMC:CPM-HA Hybrid Dermal Fillers: Findings From a Delphi Panel

Area of Science:

• Aesthetic Medicine
• Dermatology
• Cosmetic Surgery

Background:

• Minimally invasive aesthetic procedures, particularly dermal fillers, have seen a global surge in popularity.
• Hybrid dermal fillers, such as CaHA-CMC:CPM-HA, offer tailored treatments with proven efficacy and tolerability.
• Limited standardized guidance exists for the clinical application of these advanced hybrid fillers.

Purpose of the Study:

• To achieve expert consensus on the practical application of CaHA-CMC:CPM-HA hybrid dermal fillers.
• To establish standardized usage guidelines for aesthetic healthcare professionals (HCPs).

Main Methods:

• A modified Delphi process involving 23 international aesthetic HCPs.
• Development and multi-round evaluation of statements derived from scientific advisory boards and literature reviews.
• Consensus defined as ≥80% agreement/disagreement among experts.

Main Results:

• Consensus achieved on the safety, efficacy, and indications for CaHA-CMC:CPM-HA hybrid fillers.
• Specific recommendations were established for dilution ratios, injection techniques (e.g., "foaming"), and anatomical site selection.
• Experts noted synergistic benefits and convenience, alongside a need for further research on long-term safety and rheology.

Conclusions:

• The consensus provides a foundational framework for standardized hybrid dermal filler use.
• Expert agreement highlights a unified stance on the indications, efficacy, and safety of CaHA-CMC:CPM-HA fillers.
• These guidelines aim to promote effective and safe clinical practices in aesthetic treatments.