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Identifying Risk Factors of Major Adverse Cardiac Events in Patients With Ulcerative Colitis: A Retrospective
Tomohisa Takagi1, Linghua Xu2, Masato Hoshi3
1Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Journal of Gastroenterology and Hepatology
|December 12, 2024
Summary
Major adverse cardiac events (MACE) occurred in 0.8% of Japanese ulcerative colitis (UC) patients. Advanced age, diabetes, and atrial fibrillation were key risk factors for MACE in this population.
Area of Science:
- Cardiology
- Gastroenterology
- Epidemiology
Background:
- Limited data exist on Major Adverse Cardiac Events (MACE) in Japanese ulcerative colitis (UC) patients.
- Existing studies show inconsistencies and lack real-world representation.
Purpose of the Study:
- To determine MACE incidence rates in Japanese UC patients.
- To identify potential risk factors for MACE in this population.
Main Methods:
- Retrospective study using administrative claims data (2013-2022).
- Included UC patients aged ≥20 years.
- Kaplan-Meier method for cumulative incidence; Cox regression for risk factors.
Main Results:
- 91 out of 11,407 patients (0.8%) experienced MACE.
- 120-month cumulative incidence rate was 2.86%.
- Risk factors included age (≥65 years), diabetes, and atrial fibrillation (AF).
Conclusions:
- The cumulative incidence of MACE in Japanese UC patients is 2.86% over 10 years.
- Age, diabetes, AF, and a history of stroke are significant risk factors for MACE.
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